Nucleoside Sensing

Nucleoside Sensing

A rigid molecular clip comprising bisphosphonate binding sites and aromatic sidewalls forming an electron-rich cavity is able to distinguish between nucleosides and nucleotides in aqueous solution. Neutral nucleosides as well as antibiotics derived thereof are drawn into the unpolar interior of the cleft and lead to substantial upfield-shifts in the H NMR spectrum. Nucleoside drugs can therefor...

Regulation of rRNA transcription correlates with nucleoside triphosphate sensing.

We have previously shown that the activity of the Escherichia coli rRNA promoter rrnB P1 in vitro depends on the concentration of the initiating nucleotide, ATP, and can respond to changes in ATP pools in vivo. We have proposed that this nucleoside triphosphate (NTP) sensing might contribute to regulation of rRNA transcription. To test this model, we have measured the ATP requirements for trans...

Aminonaphthalimide-based imidazolium podands for turn-on fluorescence sensing of nucleoside polyphosphates.

New aminonaphthalimide imidazolium podands, which worked as luminescence chemosensors for selectively sensing nucleoside polyphosphates through a "turn-on" manner, were prepared for fluorescent imaging of ADP and ATP in living cells.

Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters

Concentrative nucleoside transporters (CNTs) are responsible for cellular entry of nucleosides, which serve as precursors to nucleic acids and act as signaling molecules. CNTs also play a crucial role in the uptake of nucleoside-derived drugs, including anticancer and antiviral agents. Understanding how CNTs recognize and import their substrates could not only lead to a better understanding of ...

Chemical Synthesis of Nucleoside Analogues Chemical Synthesis of Nucleoside Analogues